MALE FERTILITY

What Causes Male Infertility, and What Can Be Done About It

Male factor contributes to about half of all cases and produces no symptoms at all. Where the problem actually sits, how to read a semen analysis, and why a change today takes three months to show.

Reviewed by Dr. Grishma Ranjangaonkar, MBBS, DGO, ICOG Fellowship in Gynecological Endoscopy · Eva WomanCare Clinic, Vashi, Navi Mumbai

A man can feel entirely well, have normal sex drive and normal erections, and still be the reason a couple is not conceiving. Male factor has no symptoms, which is precisely why the test that finds it is so often left until last. This is what causes it, what the report means, and what can actually be done.

The short version

  • Male factor contributes to roughly half of all cases of difficulty conceiving, and produces no symptoms whatsoever.
  • WHO reference limits are fifth-percentile values, not pass marks. One in twenty men with normal fertility sits below any given line.
  • Sperm take about 74 days to make, so an abnormal result is repeated after twelve weeks and lifestyle changes take three months to show.

What this guide covers

Start here: this is half the picture

Male factor contributes to roughly half of all cases of difficulty conceiving, either on its own or alongside a female factor. It produces no symptoms whatsoever. A man can feel completely well, have a normal sex drive and normal erections, and have a semen analysis that explains everything.

Despite that, the semen analysis is routinely the last test ordered. We see couples who have spent eighteen months on cycle tracking, hormone panels and tubal tests before anyone asked the husband for a sample that costs a fraction of any of it and takes one morning.

Where the problem actually sits

Almost every cause falls into one of three groups, and knowing which group you are in decides the treatment.

Why a change today takes three months to show

Sperm take roughly seventy-four days to be made, plus a couple of weeks to mature and travel. That single fact explains most of the confusion about timing.

Made in the testis, about 74 daysMaturing0153045607590Days from the change you makeYou stop smoking todayIt reaches a sampleThis is why an abnormal semen analysis is repeated after about twelve weeks rather than next month, and why lifestyle changes arestarted three months before anyone expects to see them in a result.
The production cycle, and what it means for testingWhatever you change today shows up in a sample about three months later. It is also why an abnormal result is repeated after twelve weeks rather than next month.

It also means a single abnormal result is not a diagnosis. Semen parameters swing considerably in the same man from week to week, with illness, fever, sleep, stress and the abstinence period all moving the numbers. A fever from a viral illness six weeks ago can produce a poor result today in a man whose fertility is entirely normal.

A couple sits on a bed looking concerned and contemplative in a dimly lit room.
A poor first result is common and frequently temporary. It should be repeated after about twelve weeks before anyone draws conclusions from it.

How to read a semen analysis

Results are reported against reference limits published by the World Health Organization, most recently revised in 2021. These are the single most misread numbers in fertility medicine, so it is worth being precise about what they are.

What actually helps

A great deal is sold to men in this position. Very little of it has evidence behind it. These do.

What treatment looks like

The choice between IUI and IVF turns largely on how much motile sperm there is to work with. Our IUI guide covers where it can help and where it cannot, and the IVF guide explains ICSI, including the two variants of it that are sold as upgrades and are not recommended.

Myth

“If he can perform normally, his fertility is fine.”

What is actually true

The two are almost unrelated. Sperm production is invisible and produces no symptoms. A man with entirely normal erections, libido and ejaculation can have azoospermia. This is the belief that delays testing more than any other.

Myth

“It is the wife’s problem until proven otherwise.”

What is actually true

Male factor contributes to about half of cases. Starting the investigation with only one partner is not neutral, it is an assumption, and it costs months.

Myth

“One bad report means he is infertile.”

What is actually true

It means one sample on one day was below a reference limit. Parameters swing with illness, fever, sleep and abstinence. Repeat after about twelve weeks before concluding anything.

Myth

“Tight underwear is a major cause.”

What is actually true

The effect of clothing is small at most and gets far more attention than it deserves. Smoking, steroids, a varicocele and significant obesity are the things actually worth acting on.

Myth

“Nothing can be done about severe male factor.”

What is actually true

ICSI changed this completely. Even where very few sperm can be found, including sperm retrieved surgically from the testis, fertilization is often possible. The situations with no options at all are now uncommon.

What to do this week

A couple consults a female doctor for preconception care advice.
Come to the first appointment together if you can. Half the investigation concerns him, and it is a much better conversation with both people in the room.

Semen parameters are the World Health Organization 2021 lower reference limits, which are fifth-percentile values derived from men whose partners conceived within twelve months rather than pass marks. Indications for ICSI and the position on advanced sperm selection techniques follow NICE guideline NG257. This article is general information and does not replace advice from your own doctor, who has your history and your results.

Dr. Grishma Ranjangaonkar, gynecologist at Eva WomanCare Clinic, Vashi

Dr. Grishma Ranjangaonkar

MBBS, DGO · ICOG Fellowship in Gynecological Endoscopy · Maharashtra Medical Council Reg. No. 2014041327

Dr. Grishma has more than fifteen years of clinical experience and practises at Eva WomanCare Clinic in Vashi, seeing women from across Navi Mumbai including Kopar Khairane and Turbhe. Her work spans fertility and pregnancy care, PCOS and menstrual health, and keyhole gynecological surgery.

About Dr. Grishma  ·  Book an appointment

Read next

Trying to Conceive Guide

The full picture for both partners, including when to stop trying alone and come in.

IUI Guide

Where concentrating the motile sperm helps, and the point below which it cannot.

IVF Guide

Including ICSI, and the two variants of it sold as upgrades that guidance does not support.

Ovulation Calculator

For timing while the tests are being arranged, worked out from her own cycle length.

One sample answers a very large question

A semen analysis is inexpensive, takes one morning, and a normal result closes off half the investigation immediately. If you have been trying for months and it has not been done, that is the appointment to make. Come together if you can.

Questions men ask us most

Almost never. Sex drive, erections and ejaculation are usually completely normal, and there is no pain and nothing to notice. That is exactly why the semen analysis matters: it is the only way to know, and it is the reason the test should be done early rather than after months of investigating his partner.
No, that is normal. Morphology is assessed against strict criteria and four percent is the lower reference limit, not a failing grade. It is one of the most alarming-looking numbers on the report and one of the least often explained.
About three months. Sperm take roughly seventy-four days to be made, plus a couple of weeks to mature and travel. That is why an abnormal result is repeated after twelve weeks, and why it is worth starting changes now rather than waiting for the result.
It can. A varicocele is a collection of enlarged veins around the testis and it is one of the more common findings in men with abnormal parameters. Surgical repair is considered in selected men and can improve parameters over several months, though it is not the right answer for everyone with one.
They do the opposite. Testosterone and anabolic steroids shut down the body’s own sperm production, sometimes for many months after stopping. It is the most commonly missed cause we see in younger men, it is usually reversible, and recovery takes time, so it is worth disclosing early.
Not necessarily, and even where it is, the outlook is far better than most men expect. ICSI injects a single sperm directly into each egg, so very small numbers can be enough, including sperm retrieved surgically from the testis where none appears in the sample. Mild reductions are often handled with IUI first.
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